Fungal Reduction of C6α,β-Unsaturated Carboxylic Acids

Oxidative cleavage of unsaturated carboxylic acids (US)

Oxidative cleavage of unsaturated carboxylic acids (US CON)

Microbial reduction of aromatic carboxylic acids.

Several benzoic, cinnamic and phenylacetic acid derivatives were screened with 20 micro-organisms, mainly fungi, for the reduction of their carboxylic function. For all organisms several compounds were reduced in fairly good yields up to 80% to the corresponding alcohol. No general rule could be established, concerning the substitution pattern, as to which compounds were transformed to the alco...

Cp2TiCl2-catalyzed hydrocarboxylation of alkynes with CO2: formation of α,β-unsaturated carboxylic acids

a,b-Unsaturated carboxylic acids are important chemicals, and can be used as basic materials in the production of plastics, superabsorbent, polymers, and rubbers. Various synthetic methodologies for their synthesis have been developed, for example, oxidation of propene over heterogeneous catalysts at high temperature yielded the a,b-unsaturated carboxylic acids and hydrocarboxylation of alkynes...

Synthesis of substituted nitroolefins: a copper catalyzed nitrodecarboxylation of unsaturated carboxylic acids.

A novel, mild and convenient method for the nitrodecarboxylation of substituted cinnamic acid derivatives to their nitroolefins is achieved using a catalytic amount of CuCl (10 mol%) and tertbutyl nitrite (2 equiv.) as a nitrating agent in the presence of air. This reaction provides a useful method for the synthesis of β,β-disubstituted nitroolefin derivatives, which are generally difficult to ...